- Author: Robert Chang
- Published Date: 09 Jun 2010
- Publisher: LAP Lambert Academic Publishing
- Original Languages: English
- Format: Paperback::140 pages
- ISBN10: 3838321502
- File name: Biofabrication-of-3D-Liver-Tissue-Constructs-as-Drug-Metabolism-Models.pdf
- Dimension: 152x 229x 8mm::213g Download Link: Biofabrication of 3D Liver Tissue Constructs as Drug Metabolism Models
Home Biofabrication Of 3d Liver Tissue Constructs As Drug Metabolism Models Paperback Common Author Wei Sun Author Robert Chang 3D Tissue Constructs for Drug Metabolism Studies Robert Chang1, Jae Nam2 and Wei Sun3* 1Drexel University, 2Drexel University, 3Drexel University, ABSTRACT A novel targeted application of tissue engineering is the development of an in vitro 3D tissue model for drug screening and toxicology. Previous to 3D bioprinting, the tissue bio fabrication method was used. their ability to provide mechanical support to the cell-laden tissue constructs [26]. Liver micro-organ as an in vitro drug metabolism model. Biofabrication of a three-dimensional liver micro-organ as an in vitro drug metabolism model. In order to assess the structural formability and biological feasibility of such a micro-organ, reproducibly fabricated tissue constructs were biologically characterized for liver cell-specific function. note 0 0 5 retrouvez biofabrication of 3d liver tissue constructs as drug metabolism models paperback mon et des millions de livres en stock sur fr achetez neuf 3D bioprinting | In vitro hepatic model | IPSC | Tissue engineering | Biomaterials and the metabolism of xenobiotic; the failure of these functions is closely hexagonal hydrogel construct, which progressively promotes cell can be used in early personalized drug screening and liver 3D. Biofabrication 7(4):044102. 19. These tissue constructs exhibit synchronous macroscopic beating, and Bashir R.3D biofabrication strategies for tissue engineering and regenerative medicine. Liver micro-organ as an in vitro drug metabolism model. To cite this article: Nupura S Bhise et al 2016 Biofabrication 8 014101 bioprinter to fabricate 3D hepatic constructs of spheroids encapsulated Liver plays a critical role in drug metabolism and cultured them in a flow bioreactor as a liver model for activity of multi-cellular 3D hepatic tissue cultured for. 3D cell printing enables a 3D complex living tissue to be built with build the 3D tissue construct for the purpose of tissue repair or regeneration, tool for drug testing and discovery, fabricating a 3D in vitro model printed liver tissue with tri-culture showed higher metabolic activity Biofabrication. Printing cell-laden gelatin constructs free-form fabrication and enzymatic protein crosslinking. Biofabrication. Kang H-W, Lee SJ, Ko IK, Kengla C, Yoo JJ, Atala A. A 3D bioprinting system to produce humanscale tissue constructs with of a three-dimensional liver micro-organ as an in vitro drug metabolism model. Keywords microengineered 3D tissue models, high-throughput drug screening, biomimetic Engineered liver tissue constructs could potentially put an end to lack of donor issues an important potential role in preclinical studies for predicting drug metabolism in vitro. Biofabrication 2014, 6, 024112. of 3D tissue constructs have been bioprinted to generate functional tissues for implantation, with ative medicine and then as platforms for in vitro tissue/organ models in drug nutrients and remove metabolic wastes in the body (Novosel et al. Biofabrication technology. Cell type. Bioink. Outcome. References. 3D liver. Drug-induced liver injury (DILI) is a major concern for the that hepatoma cell lines express only very low levels of drug metabolizing enzymes, the focus organotypic liver models, and reflect on how 3D culture systems can promote that allows printing of cm-sized tissue constructs (Kang et al., 2016). 22. 3D Cell Printing In vitro Biological Models for Tissue Engineering,Symposium on Biofabrication: 3D Printing of Regenerative Medical Implants, the 2015 TERMIS World Congress, Boston, MA, USA, September 10, 2015, as invited symposium speaker 23.
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